Why Chronic Depression Can Be Aggravated By a Hidden Toxoplasmosis Infection
For people diagnosed with Lyme disease that feel stuck in a dark pit of hopelessness and depression
by Greg Lee
Imagine you are part of a rescue team that is working to rescue miners that are trapped in a mine collapse. You are your colleagues are racing against time to rescue the survivors before their air runs out. Using sensitive listening technology, you determined there are sounds which indicate possible survivors. Your rescue team works diligently, quickly, and safely to clear a path through blocked tunnels while reinforcing walls to prevent further collapse.
How being trapped in an underground mine similar to hopelessness and depression in a person diagnosed with Lyme disease?
Just like being trapped in an underground mine, people with Lyme disease can feel hopeless and deeply depressed
Over a two year period, Fred went to several different Lyme literate specialists. He took medications for treating Lyme disease, Babesia, Bartonella, biofilms, viruses, and Candida. He also took antidepressants, sleep medications, allergy medications, and steroids. Despite years of medications, he still suffered with insomnia, disabling joint pain, and fatigue. However, the emotional mood swings were the most difficult to endure.
Fred would often feel like he was at the bottom of a dark emotional pit
After struggling with the same symptoms for years, he felt afraid he would never get better. Medications for Babesia dramatically increased his anxiety and hopelessness. He tried saunas, IV magnesium, and lymphatic drainage to get rid of toxins which reduced his symptoms temporarily. However, the depression and hopelessness persisted. In desperation, he went to an alternative Lyme practitioner and got a big surprise.
Fred tested positive for a protozoa infection called Toxoplasmosis
Results from an electrodermal scan that checked for over four hundred possible infections showed toxoplasmosis as the biggest stressor on his system. Symptoms of a toxoplasmosis infection include: flu-like symptoms with swollen lymph glands or muscle aches and pains that last for a month or more. Severe toxoplasmosis, can cause damage to the brain, eyes, or other organs. Severe cases can develop from an acute toxoplasma infection or a latent infection that is being reactivated. People with weakened immune systems are more at risk. Occasionally, healthy people may have eye damage from toxoplasmosis which can include reduced vision, blurred vision, pain (often with bright light), redness of the eye, and sometimes tearing. A small percentage of infected newborns may have serious eye or brain damage at birth. Most have no symptoms at birth, and may develop symptoms later in life¹. Anti-malarial medications are effective at killing off toxoplasmosis.
Anti-toxoplasmosis medications can have dramatic side-effects
Anti-malarial medications like Mepron (atovaquone) which are used for treatment of toxoplasmosis can produce side-effects of erythema rashes, gastrointestinal discomfort, headaches, insomnia, fever, and liver function test abnormalities². Other anti-malarial remedies, Deraprim (pyrimethamine) and artemisinin are also used to treat toxoplasmosis. Unfortunately, Mepron³, Deraprim⁴, and artemisinin⁵resistant strains of toxoplasmosis are common. Drug resistance genes have also been transferred from malaria parasites to toxoplasma protozoa in lab experiments⁶. Toxoplasmosis can dramatically affect brain chemistry and a person’s emotions.
Toxoplasmosis has been correlated with depression and suicide
Toxoplasmosis is estimated to infect a third of all humans on earth and is increasing. This infection has been linked with depression, violent suicides, and schizophrenia.⁷ Over 60 million people, which is around 22% of the population in the United States, are carriers of it. Toxoplasmosis is transmitted by eating infected food, drinking contaminated water, organ transplant, blood transfusion, passed from an infected mother to an unborn child⁸, or possibly from ticks⁹. In different animal studies, this infection can stimulate the production of inflammatory compounds called cytokines including: interferon (IFN-gamma), Interleukin (IL)-6, IL-12, IL-23, tumor necrosis factor (TNF)-alpha¹⁰, IL-1, and granulocyte/macrophage colony-stimulating factor (GM-CSF)¹¹. Some of these cytokines can penetrate into the brain and can change a person’s mood. The cytokines IL-6 and TNF have been linked to a depletion of tryptophan and seritonin which may produce increased levels of anxiety, impulsiveness, and rapid changes in emotion¹².
What else besides medications can help to relieve dark depression and hopelessness caused by toxoplasmosis?
These five strategies help to reduce depression caused by a drug-resistant toxoplasmosis infection
These five strategies can help to reduce the anxiety, depression, and muscle pains from a toxoplasmosis infection. These strategies have demonstrated in lab and animal experiments the ability to inhibit toxoplasmosis and the inflammatory compounds that can affect mood swings. These strategies can be used simultaneously to promote a rapid shift in physical and emotional discomfort.
Strategy #1: Liposomal Anti-toxoplasmosis Remedies
Liposomes are very small particles which have a medication or a natural remedy in the center are surrounded by a fat called a lipid. Liposomal medications have been shown to more effective at fighting other protozoa infections¹³. Liposomal herbal remedies may be an effective alternative for reducing symptoms caused by drug-resistant toxoplasmosis. Fred received a liposomal mixture containing myrrh¹⁴, sophora¹⁵, artemisia¹⁶, harmine which is an extract of syrian rue¹⁷, astragalus and scutellaria¹⁸ which helped to reduce emotional mood swings and muscle aches and pains.
Liposomal medications have also been shown to target tissues in the brain more effectively in animal studies¹⁹. Other herbs were added to the liposomal mixture to help reduce brain inflammation caused by IL-6 or TNF included: licorice²⁰, cordyceps mushroom²¹, and coptis²². In addition to liposomal herbs, probiotics can help protect against toxoplasmosis.
Strategy #2: Probiotics and Prebiotics
Probiotics are the healthy bacteria in the gut which help to digest food, train the immune system, and resist pathogens²³. In one rat study, a combination of Bifidobacterium animalis and fructooligosaccharides enabled rats to survive a toxoplasmosis infection. All the rats who didn’t receive the probiotic perished²⁴. Fructooligosaccharide is a sweetener that feeds probiotic bacteria, also known as a prebiotic. Supplements can also help fight a toxoplasmosis infection.
Strategy #3: Supplements
In animal and lab studies, several supplements have enhanced the immune response to toxoplasmosis including: zinc, melatonin²⁵, lactoferrin inhibits the development of intracellular parasites²⁶, and silver nanoparticles alone or combined with chitosan decreased the mean number of parasites in the liver and spleen²⁷. Fred was given a silver nanoparticle solution to take sublingually every day to promote penetration into his nervous system. This silver solution was also imprinted with electrical frequencies that have anti-toxoplasmosis properties. He reported die off reactions in the first several weeks of taking the remedy. Microcurrent treatment can also help with reducing parasites and brain inflammation.
Strategy #4: Frequency Specific Microcurrent
Frequency Specific Microcurrent uses very low power, millionth of an amp, electrical currents to reduce single cell parasites and their toxins²⁸. In addition, frequencies can also be used to reduce inflammation in many different areas of the brain including the forebrain where the amygdala, thalamus, and hippocampus are. These structures are associated with emotional changes, depression, and anxiety. Fred’s anxiety decreased significantly after receiving Frequency Specific Microcurrent treatments. Laser delivered remedies can also relieve recurring toxoplasmosis emotions.
Strategy #5: Laser Delivered Anti-toxoplasmosis Remedies
Shining a 660 nm laser through a glass vial containing a homeopathic toxoplasmosis remedy or essential oil into the ear or into painful muscles can relieve persistent symptoms²⁹. Fred felt an immediate shift in his muscle aches with the laser delivered homeopathic toxoplasmosis remedy. Shinning the laser through a vial of myrrh essential oil into the ear and next clove essential oil helped to relieve brain fog and feelings of dissociation. “My brain feels normal!” remarked Fred. A combination of multiple anti-toxoplasmosis remedies and treatments can help dramatically reduce anxiety, depression, and painful muscles aches.
Employing multiple strategies for reducing toxoplasmosis and brain inflammation helps to relieve painful emotions
Similar to rescuing a group of trapped miners, a combination of liposomal herbs, probiotics, supplements, Frequency Specific Microcurrent, and laser delivered remedies can help relieve the underlying inflammation and debilitating emotions produced by a drug resistant toxoplasmosis infection. These strategies helped Fred to reduce his anxiety and depression by over 80%. Since several of these strategies require specialized training and may produce Herxheimer reactions, work with a Lyme literate acupuncturist to develop a safe and effective strategy for relieving persistent toxoplasmosis anxiety, depression, and muscle pains.
1. Parasites – Toxoplasmosis (Toxoplasma infection). http://www.cdc.gov/parasites/toxoplasmosis/gen_info/faqs.html
2. Wreghitt, T.G. and Joynson, D.H. Toxoplasma infection in immunosuppressed (HIV-negative) patients. in: D.H. Joynson, T.G. Wreghitt (Eds.) Toxoplasmosis: a comprehensive clinical guide. Cambridge University Press, Cambridge; 2001: p. 328.
3. Pfefferkorn ER, Borotz SE, Nothnagel RF. Mutants of Toxoplasma gondii resistant to atovaquone (566C80) or decoquinate. J Parasitol. 1993 Aug;79(4):559-64. http://www.ncbi.nlm.nih.gov/pubmed/8331476
4. KAUFMAN HE, REMINGTON J, MELTON ML, JACOB SL. Relative resistance of slow-growing strains of Toxoplasma gondii to pyrimethamine (daraprim). Arch Ophthalmol. 1959 Oct;62:611-5. http://www.ncbi.nlm.nih.gov/pubmed/14404853
5. K. Nagamune, Moreno, S. Sibley, L. Artemisinin-Resistant Mutants of Toxoplasma gondii Have Altered Calcium Homeostasis. Antimicrob Agents Chemother. 2007 November; 51(11): 3816-3823. Published online 2007 August 13. doi: 10.1128/AAC.00582-07. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151471/
6. Donald RG, Roos DS. Stable molecular transformation of Toxoplasma gondii: a selectable dihydrofolate reductase-thymidylate synthase marker based on drug-resistance mutations in malaria. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11703-7. http://www.ncbi.nlm.nih.gov/pubmed/8265612
7. Pedersen MG, Mortensen PB, Norgaard-Pedersen B, Postolache TT. Toxoplasma gondii infection and self-directed violence in mothers. Arch Gen Psychiatry. 2012 Nov;69(11):1123-30. http://archpsyc.jamanetwork.com/article.aspx?articleid=1206779
8. Parasites – Toxoplasmosis (Toxoplasma infection). Epidemiology & Risk Factors. http://www.cdc.gov/parasites/toxoplasmosis/epi.html
9. Sroka J, Chmielewska-Badora J, Dutkiewicz J. Ixodes ricinus as a potential vector of Toxoplasma gondii. Ann Agric Environ Med. 2003;10(1):121-3. http://www.ncbi.nlm.nih.gov/pubmed/12852744
10. M Deckert-Schlüter, S Albrecht, H Hof, O D Wiestler, and D Schlüter. Dynamics of the intracerebral and splenic cytokine mRNA production in Toxoplasma gondii-resistant and -susceptible congenic strains of mice. Immunology. Jul 1995; 85(3): 408-418. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1383914/
11. Fischer HG, Nitzgen B, Reichmann G, Hadding U. Cytokine responses induced by Toxoplasma gondii in astrocytes and microglial cells. Eur J Immunol. 1997 Jun;27(6):1539-48. http://www.ncbi.nlm.nih.gov/pubmed/9209508
12. Okusaga O, Postolache TT. Toxoplasma gondii, the Immune System, and Suicidal Behavior. In: Dwivedi Y, editor. The Neurobiological Basis of Suicide. Boca Raton (FL): CRC Press; 2012. Chapter 19. Available from: http://www.ncbi.nlm.nih.gov/books/NBK107197/
13. Barratt G, Legrand P. Comparison of the efficacy and pharmacology of formulations of amphotericin B used in treatment of leishmaniasis. Curr Opin Infect Dis. 2005 Dec;18(6):527-30. http://www.ncbi.nlm.nih.gov/pubmed/16258327
14. Al-Zanbagi NA. Effectiveness of Myrrh and Spiramycin as Inhibitors for Toxoplasma gondii Tachyzoites In Vivo. Mansoura Journal of Forensic Medicine and Clinical Toxicology. 2007;15(2):117-28.
15. Youn HJ, Lakritz J, Kim DY, Rottinghaus GE, Marsh AE. Anti-protozoal efficacy of medicinal herb extracts against Toxoplasma gondii and Neospora caninum. Vet Parasitol. 2003 Aug 29;116(1):7-14. http://www.ncbi.nlm.nih.gov/pubmed/14519322
16. de Oliveira TC, Silva DA, Rostkowska C, BÃ(c)la SR, Ferro EA, MagalhÃ£es PM, Mineo JR. Toxoplasma gondii: effects of Artemisia annua L. on susceptibility to infection in experimental models in vitro and in vivo. Exp Parasitol. 2009 Jul;122(3):233-41. doi: 10.1016/j.exppara.2009.04.010. Epub 2009 Apr 21. http://www.ncbi.nlm.nih.gov/pubmed/19389400
17. Alomar ML, Rasse-Suriani FA, Ganuza A, Cóceres VM, Cabrerizo FM, Angel SO. In vitro evaluation of β-carboline alkaloids as potential anti-Toxoplasma agents. BMC Res Notes. 2013 May 10;6:193. doi: 10.1186/1756-0500-6-193. http://www.ncbi.nlm.nih.gov/pubmed/23663567
18. Yang X, Huang B, Chen J, Huang S, Zheng H, Lun ZR, Shen J, Wang Y, Lu F. In vitro effects of aqueous extracts of Astragalus membranaceus and Scutellaria baicalensis GEORGI on Toxoplasma gondii. Parasitol Res. 2012 Jun;110(6):2221-7. doi: 10.1007/s00436-011-2752-2. Epub 2011 Dec 17. http://www.ncbi.nlm.nih.gov/pubmed/19389400
19. Huang YB, Tsai MJ, Wu PC, Tsai YH, Wu YH, Fang JY. Elastic liposomes as carriers for oral delivery and the brain distribution of (+)-catechin. J Drug Target. 2011 Sep;19(8):709-18. doi: 10.3109/1061186X.2010.551402. Epub 2011 Feb 8. http://www.ncbi.nlm.nih.gov/pubmed/21303222
20. Okuma Y, Liu K, Wake H, Liu R, Nishimura Y, Hui Z, Teshigawara K, Haruma J, Yamamoto Y, Yamamoto H, Date I, Takahashi HK, Mori S, Nishibori M. Glycyrrhizin inhibits traumatic brain injury by reducing HMGB1-RAGE interaction. Neuropharmacology. 2014 May 20;85C:18-26. doi: 10.1016/j.neuropharm.2014.05.007. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/24859607
21. Shin S, Lee S, Kwon J, Moon S, Lee S, Lee CK, Cho K, Ha NJ, Kim K. Cordycepin Suppresses Expression of Diabetes Regulating Genes by Inhibition of Lipopolysaccharide-induced Inflammation in Macrophages. Immune Netw. 2009 Jun;9(3):98-105. doi: 10.4110/in.2009.9.3.98. Epub 2009 Jun 30. http://www.ncbi.nlm.nih.gov/pubmed/20107539
22. Choi YY, Kim MH, Cho IH, Kim JH, Hong J, Lee TH, Yang WM. Inhibitory effect of Coptis chinensis on inflammation in LPS-induced endotoxemia. J Ethnopharmacol. 2013 Sep 16;149(2):506-12. doi: 10.1016/j.jep.2013.07.008. Epub 2013 Jul 18. http://www.ncbi.nlm.nih.gov/pubmed/23871807
23. Shoaie S, Nielsen J. Elucidating the interactions between the human gut microbiota and its host through metabolic modeling. Front Genet. 2014 Apr 22;5:86. eCollection 2014. http://www.ncbi.nlm.nih.gov/pubmed/24795748
24. Ribeiro CM, Costa VM, Gomes MI, Golim MA, Modolo JR, Langoni H. Effects of synbiotic-based Bifidobacterium animalis in female rats experimentally infected with Toxoplasma gondii. Comp Immunol Microbiol Infect Dis. 2011 Mar;34(2):111-4. doi: 10.1016/j.cimid.2010.03.002. Epub 2010 Apr 20. http://www.ncbi.nlm.nih.gov/pubmed/20409588
25. Baltaci AK, Bediz CS, Mogulkoc R, Kurtoglu E, Pekel A. Effect of zinc and melatonin supplementation on cellular immunity in rats with toxoplasmosis. Biol Trace Elem Res. 2003 Winter;96(1-3):237-45. http://www.ncbi.nlm.nih.gov/pubmed/14716103
26. Dzitko K, Dziadek B, Dziadek J, Długońska H. Toxoplasma gondii: inhibition of the intracellular growth by human lactoferrin. Pol J Microbiol. 2007;56(1):25-32. http://www.ncbi.nlm.nih.gov/pubmed/17419186
27. Gaafar MR, Mady RF, Diab RG, Shalaby TI. Chitosan and silver nanoparticles: Promising anti-toxoplasma agents.Exp Parasitol. 2014 May 19. pii: S0014-4894(14)00119-2. doi: 10.1016/j.exppara.2014.05.005. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/24852215
28. Frequency Specific Microcurrent Advanced Summary Protocols. http://www.frequencyspecific.com/faq.php#protocol
29. Cowden, L. Change the Terrain To Resolve Disease. 2012 Physician’s Round Table. January 28th, 2012. Tampa, FL